https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53713 Wed 28 Feb 2024 16:37:14 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53856 Wed 28 Feb 2024 15:05:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45218 Wed 26 Oct 2022 15:56:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55329 Wed 15 May 2024 15:47:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37505 Wed 02 Mar 2022 14:28:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48543 Tue 21 Mar 2023 15:42:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39881 Tue 04 Oct 2022 15:37:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52625 Thu 19 Oct 2023 15:04:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34741 Thu 17 Feb 2022 09:29:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40019 n = 388) and CHHiP (up to n = 247) trials onto the same exemplar and repeating the voxel-based tests on each of these data sets. All three datasets were then combined, and the tests repeated. Results: Voxel-based Cox regression and multiple comparison permutation dose difference testing revealed regions where increased dose was correlated with genitourinary toxicity. Increased dose in the vicinity of the membranous and spongy urethra was associated with dysuria for all datasets. Haematuria was similarly correlated with increased dose at the membranous and spongy urethra, for the RADAR, CHHiP, and combined datasets. Some evidence was found for the association between incontinence and increased dose at the internal and external urethral sphincter for RADAR and the internal sphincter alone for the combined dataset. Incontinence was also strongly correlated with dose from posterior oblique beams. Patients with fields extending inferiorly and posteriorly to the CTV, adjacent to the membranous and spongy urethra, were found to experience increased frequency. Conclusions: Anatomically-localized dose-toxicity relationships were determined for late genitourinary symptoms in the urethra and urinary sphincters. Low-intermediate doses to the extraprostatic urethra were associated with risk of late dysuria and haematuria, while dose to the urinary sphincters was associated with incontinence.]]> Thu 14 Jul 2022 13:55:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37248 50 = 116.7 Gy and m = 0.23; n was fixed to 0.3, based on numerical optimization of the likelihood. The calibration plot showed a good agreement between the observed toxicity and the probability predicted by the model, confirmed by bootstrapping. For the external validation, the calibration plot showed that the observed toxicity obtained with the RADAR patients was well-represented by the fitted LKB model parameters. When patients were stratified by the use of AD TD₅₀ decreased when AD was not present. Conclusions: Lyman–Kutcher–Burman model parameters were fitted to the risk of urethral stricture and externally validated with an independent cohort, to provide guidance on urethral tolerance doses for patients treated with a HDRB boost. For patients that did not receive AD, model fitting provided a lower TD₅₀ suggesting a protective effect on urethra toxicity.]]> Thu 09 Dec 2021 11:03:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52863 Mon 30 Oct 2023 10:01:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38230 Mon 16 Aug 2021 16:29:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39586 in silico using the Kaplan-Meier Plotter (n=3,935), the TCGA invasive breast carcinoma (n=960) and GOBO (n=821) data sets. Functional effects of BAALC expression on breast cancer proliferation, migration and invasion were determined in vitro. We demonstrate herein that BAALC expression is progressively increased in primary and breast cancer metastases when compared to normal breast tissue. Increased BAALC mRNA is associated with a reduction in DMFS and disease-free survival, but not OS, in breast cancer patients, even when corrected for tumor grade. We show that overexpression of BAALC in MCF-7 breast cancer cells increases the proliferation, anchorage-independent growth, invasion, and migration capacity of these cells. Conversely, siRNA knockdown of BAALC expression in Hs578T breast cancer cells decreases proliferation, invasion and migration. We identify that this BAALC associated migration and invasion is mediated by focal adhesion kinase (FAK)-dependent signaling and is accompanied by an increase in matrix metalloproteinase (MMP)-9 but not MMP-2 activity in vitro. Our data demonstrate a novel function for BAALC in the control of breast cancer metastasis, offering a potential target for the generation of anti-cancer drugs to prevent breast cancer metastasis.]]> Mon 08 Aug 2022 11:48:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39977 Fri 22 Jul 2022 11:56:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51723 Fri 15 Sep 2023 17:53:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51353 Fri 01 Sep 2023 13:35:36 AEST ]]>